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1

Stopped-Flow Calcium Association Kinetics of Hypertrophic Cardiomyopathy Associated Troponin T Mutations

Klass, Matthew M., Lehman, Sarah J., Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2018

Language:

english

File:

PDF, 64 KB

english, 2018

2

Sarcomeric Proteins and Familial Hypertrophic Cardiomyopathy: Linking Mutations in Structural Proteins to Complex Cardiovascular Phenotypes

Journal:

Heart Failure Reviews

Year:

2005

Language:

english

File:

PDF, 224 KB

english, 2005

3

Cardiac troponin T mutations: correlation between the type of mutation and the nature of myofilament dysfunction in transgenic mice

David E. Montgomery, Jil C. Tardiff, Murali Chandra

Journal:

The Journal of Physiology

Year:

2001

Language:

english

File:

PDF, 202 KB

english, 2001

4

Molecular Effects of Familial Hypertrophic Cardiomyopathy-Related Mutations in the TNT1 Domain of cTnT

Edward P. Manning, Jil C. Tardiff, Steven D. Schwartz

Journal:

Journal of Molecular Biology

Year:

2012

Language:

english

File:

PDF, 1.15 MB

english, 2012

5

Independent FHC-related cardiac troponin T mutations exhibit specific alterations in myocellular contractility and calcium kinetics

Todd E. Haim, Candice Dowell, Theodhor Diamanti, James Scheuer, Jil C. Tardiff

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2007

Language:

english

File:

PDF, 1.13 MB

english, 2007

6

Cardiac myosin heavy chain isoform exchange alters the phenotype of cTnT-related cardiomyopathies in mouse hearts

Ron Rice, Pia Guinto, Candice Dowell-Martino, Huamei He, Kirsten Hoyer, Maike Krenz, Jeffrey Robbins, Joanne S. Ingwall, Jil C. Tardiff

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2010

Language:

english

File:

PDF, 1.15 MB

english, 2010

7

A Model of Calcium Activation of the Cardiac Thin Filament

Manning, Edward P., Tardiff, Jil C., Schwartz, Steven D.

Journal:

Year:

2011

Language:

english

File:

PDF, 4.33 MB

english, 2011

8

Effects of R92 mutations in mouse cardiac troponin T are influenced by changes in myosin heavy chain isoform

Steven J. Ford, Ranganath Mamidi, Jesus Jimenez, Jil C. Tardiff, Murali Chandra

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2012

Language:

english

File:

PDF, 927 KB

english, 2012

9

Functional and Structural Changes Induced By cTNT-Related FHC Mutations in TNT1 Alter Actomyosin Binding Interactions

Moore, Rachel K., Guinto, Pia J., Dowell-Martino, Candice, Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 38 KB

english, 2010

10

Effects of R92 Mutations on Cardiac Contractile Function are Influenced by Changes in Myosin Heavy Chain Isoform

Ford, Steven J., Mamidi, Ranganath, Jimenez, Jesus J., Tardiff, Jil C., Chandra, Murali

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 41 KB

english, 2011

11

Tropomyosin and Dilated Cardiomyopathy: Revenge of the Actinomyosin “Gatekeeper”

Journal:

Journal of the American College of Cardiology

Year:

2010

Language:

english

File:

PDF, 127 KB

english, 2010

12

Myosin-driven rescue of contractile reserve and energetics in mouse hearts bearing familial hypertrophic cardiomyopathy-associated mutant troponin T is mutation-specific

He, Huamei, Hoyer, Kirsten, Tao, Hai, Rice, Ronald, Jimenez, Jesus, Tardiff, Jil C., Ingwall, Joanne S.

Journal:

The Journal of Physiology

Year:

2012

Language:

english

File:

PDF, 1.16 MB

english, 2012

13

R-92L and R-92W Mutations in Cardiac Troponin T Lead to Distinct Energetic Phenotypes in Intact Mouse Hearts

He, Huamei, Javadpour, Maryam M., Latif, Farhana, Tardiff, Jil C., Ingwall, Joanne S.

Journal:

Biophysical Journal

Year:

2007

Language:

english

File:

PDF, 482 KB

english, 2007

14

HCM-linked ∆160E cardiac troponin T mutation causes unique progressive structural and molecular ventricular remodeling in transgenic mice

Moore, Rachel K., Grinspan, Lauren Tal, Jimenez, Jesus, Guinto, Pia J., Ertz-Berger, Briar, Tardiff, Jil C.

Journal:

Journal of Molecular and Cellular Cardiology

Year:

2013

Language:

english

File:

PDF, 1.81 MB

english, 2013

15

[Biological and Medical Physics, Biomedical Engineering] Biophysics of the Failing Heart ||

Solaro, R. John, Tardiff, Jil C.

Year:

2013

Language:

english

File:

PDF, 4.19 MB

english, 2013

16

Pseudophosphorylation of Cardiac Troponin I Residues 23/24 Decreases Myofilament Ca2+ Sensitivity in Transgenic Mice Containing D230N Mutation in α-Tropomyosin

Michael, John J., Tal, Lauren, Tardiff, Jil C., Chandra, Murali

Journal:

Biophysical Journal

Year:

2013

Language:

english

File:

PDF, 45 KB

english, 2013

17

Structural and Functional Characterization of Cardiac Troponin T Mutations in the TNT1 Domain That Cause Familial Hypertrophic Cardiomyopathy

Guinto, Pia J., Manning, Edward P., Moore, Rachel K., Schwartz, Steven D., Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 40 KB

english, 2009

18

DCM-Linked D230N Tropomyosin Mutation Results in Early Dilatation and Systolic Dysfunction in Mice

Tal, Lauren, Jimenez, Jesus, Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 42 KB

english, 2012

19

Structural and Functional Characterization of the TNT1 Domain of Cardiac Troponin T

Moore, Rachel K., Guinto, Pia J., Wilson, John, Gerfen, Gary, Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2010

Language:

english

File:

PDF, 38 KB

english, 2010

20

D230N Mutation in Tropomyosin and R92L Mutation in Cardiac Troponin T have Strikingly Different Impact on Calcium-Regulated Activation of Cardiac Myofilaments

Michael, John J., Mamidi, Ranganath, Gollapudi, Sampath, Tal, Lauren, Tardiff, Jil, Chandra, Murali

Journal:

Biophysical Journal

Year:

2012

Language:

english

File:

PDF, 38 KB

english, 2012

21

A Revised Atomistic Model of the Cardiac Thin Filament and Application to a Specific Disease Causing Mutation

Williams, Michael R., Tardiff, Jil, Schwartz, Steven

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 43 KB

english, 2014

22

Allosteric effects of cardiac troponin TNT1 mutations on actomyosin binding: A novel pathogenic mechanism for hypertrophic cardiomyopathy

Moore, Rachel K., Abdullah, Salwa, Tardiff, Jil C.

Journal:

Archives of Biochemistry and Biophysics

Year:

2014

Language:

english

File:

PDF, 1.69 MB

english, 2014

23

Pathophysiologic Changes Induced by Mutations in the TNT1 Domain of cTnT that Cause FHC

Tal, Lauren, Moore, Rachel K., Dowell-Martino, Candice, Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 36 KB

english, 2011

24

Increased Myofilament Ca2+ Sensitivity Decreases Sarcomere Length and Increases Spark-Spark Interactions

Chen-Izu, Ye, Banyasz, Tamas, Khabbaz, Shaden, Edelmann, Stephanie, Payne, Charles, Tardiff, Jil C., Izu, Leighton T.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 81 KB

english, 2011

25

Computational Modeling of Cardiac Troponin Dynamics: Elucidating a Regulatory Mechanism for Calcium Activation of the Thin Filament

Manning, Edward P., Tardiff, Jil C., Schwartz, Steven D.

Journal:

Biophysical Journal

Year:

2011

Language:

english

File:

PDF, 52 KB

english, 2011

26

The Cardiac Troponin T R92L Hcm Mutation Alters Cardiac Troponin I Dynamics and PKA Phosphorylation Potential

Jayasundar, Jayant James, Brooks, Kenneth, Lehman, Sarah, Williams, Michael R., Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 43 KB

english, 2014

27

Structural and Functional Characterization of cTnT in Familial Hypertrophic Cardiomyopathy

Moore, Rachel K., Wilson, John, Guinto, Pia, Riegelhaupt, Michael, Gerfen, Gary, Tardiff, Jil

Journal:

Biophysical Journal

Year:

2009

Language:

english

File:

PDF, 40 KB

english, 2009

28

E-C Coupling Alterations and Spontaneous Activity in Mice Carrying Cardiac Troponin T Mutations

Pioner, Josè Manuel, Coppini, Raffaele, Ferrantini, Cecilia, Tosi, Benedetta, Mazzoni, Luca, Moore, Rachel, Cerbai, Elisabetta, Mugelli, Alessandro, Tardiff, Jil, Tesi, Chiara, Poggesi, Corrado

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 47 KB

english, 2014

29

Dynamic Effects of Tropomyosin D230N Mutation and Fetal Troponin T on the Tropomyosin Overlap Region

McConnell, Mark T., Jayasundar, Jayant J., Grinspan, Lauren, Fass, Ofer Z., Schwartz, Benjamin, Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 43 KB

english, 2014

30

Computational Prediction and Experimental Verification of Differential Calcium Affinity in Thin Filament Mutants Known to Cause Hypertrophic Cardiomyopathy

Manning, Edward P., Lehman, Sarah J., Schwartz, Steven D., Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 40 KB

english, 2014

31

COMPUTATIONAL CHARACTERIZATION OF MUTATIONS IN CARDIAC TROPONIN T KNOWN TO CAUSE FAMILIAL HYPERTROPHIC CARDIOMYOPATHY

GUINTO, PIA J., MANNING, EDWARD P., SCHWARTZ, STEVEN D., TARDIFF, JIL C.

Journal:

Journal of Theoretical and Computational Chemistry

Year:

2007

Language:

english

File:

PDF, 579 KB

english, 2007

32

[Biological and Medical Physics, Biomedical Engineering] Biophysics of the Failing Heart || Sarcoplasmic Reticulum Ca Homeostasis and Heart Failure

Solaro, R. John, Tardiff, Jil C.

Year:

2013

Language:

english

File:

PDF, 638 KB

english, 2013

33

[Biological and Medical Physics, Biomedical Engineering] Biophysics of the Failing Heart || Biophysics of Membrane Currents in Heart Failure

Solaro, R. John, Tardiff, Jil C.

Year:

2013

Language:

english

File:

PDF, 357 KB

english, 2013

34

[Biological and Medical Physics, Biomedical Engineering] Biophysics of the Failing Heart || Ca-Homeostasis and Heart Failure: Focus on the Biophysics of Surface Membrane Ca-Fluxes

Solaro, R. John, Tardiff, Jil C.

Year:

2013

Language:

english

File:

PDF, 216 KB

english, 2013

35

[Biological and Medical Physics, Biomedical Engineering] Biophysics of the Failing Heart || Introduction to the Biophysics of the Failing Heart

Solaro, R. John, Tardiff, Jil C.

Year:

2013

Language:

english

File:

PDF, 38 KB

english, 2013

36

[Biological and Medical Physics, Biomedical Engineering] Biophysics of the Failing Heart || Biophysical Mechanisms for the Metabolic Component of Impaired Heart Function

Solaro, R. John, Tardiff, Jil C.

Year:

2013

Language:

english

File:

PDF, 633 KB

english, 2013

37

The functional effect of dilated cardiomyopathy mutation (R144W) in mouse cardiac troponin T is differently affected by α- and β-myosin heavy chain isoforms

Gollapudi, Sampath K., Tardiff, Jil C., Chandra, Murali

Journal:

AJP Heart and Circulatory Physiology

Year:

2015

Language:

english

File:

PDF, 1.11 MB

english, 2015

38

Myosin at the Heart of the Problem

Tardiff, Jil C.

Journal:

Boston Medical and Surgical Journal

Year:

2004

Language:

english

File:

PDF, 176 KB

english, 2004

39

Intrauterine Treatment of a Fetus with Familial Hypertrophic Cardiomyopathy Secondary to MYH7 Mutation

Hill, Meghan G., Sekhon, Mehtab K., Reed, Kathryn L., Anderson, Caroline F., Borjon, Nydia D., Tardiff, Jil C., Barber, Brent J.

Journal:

Pediatric Cardiology

Year:

2015

Language:

english

File:

PDF, 645 KB

english, 2015

40

Atomic resolution probe for allostery in the regulatory thin filament

Williams, Michael R., Lehman, Sarah J., Tardiff, Jil C., Schwartz, Steven D.

Journal:

Proceedings of the National Academy of Sciences

Year:

2016

Language:

english

File:

PDF, 1.27 MB

english, 2016

41

An Explicitly Solvated Full Atomistic Model of the Cardiac Thin Filament and Application on the Calcium Binding Affinity Effects from Familial Hypertrophic Cardiomyopathy Linked Mutations

Williams, Michael R., Lehman, Sarah J., Tardiff, Jil C., Schwartz, Steven D.

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 38 KB

english, 2015

42

An Integrative Approach to Thin Filament Cardiomyopathies: From Molecular and Computational Biophysics to Mice

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 53 KB

english, 2015

43

Mechanical Remodeling of Atrial Myocardium in HCM Mouse Models Carrying CTNT Mutations

Pioner, Josè Manuel, Gentile, Francesca, Coppini, Raffaele, Scellini, Beatrice, Tardiff, Jil, Tesi, Chiara, Poggesi, Corrado, Ferrantini, Cecilia

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 71 KB

english, 2016

44

A FRET Investigation on the Effects of Tropomyosin D230N and Cardiac Troponin T R92L Mutants on the Tropomyosin Overlap Structure

McConnell, Mark T., Tal Grinspan, Lauren, Schwartz, Benjamin, Fass, Ofer Z., James Jayasundar, Jayant, Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 45 KB

english, 2016

45

Differential Effects of CaMKII Activity in HCM-Linked TNT Mutations

Lehman, Sarah J., Tal-Grinspan, Lauren, Lynn, Melissa, Anderson, Mark E., Tardiff, Jil C.

Journal:

Biophysical Journal

Year:

2016

Language:

english

File:

PDF, 45 KB

english, 2016

46

Structural Effects of Cardiac Troponin T R92L and Tropomyosin D230N Mutants in the Cardiac Thin Filament

McConnell, Mark T., Grinspan, Lauren, Tardiff, Jil

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 45 KB

english, 2015

47

Myocardial Dysfunction in Hypertrophic Cardiomyopathy: Primary Effects of Sarcomeric Mutations Versus Secondary EC-Coupling Remodelling

Coppini, Raffaele, Ferrantini, Cecilia, Gentile, Francesca, Mazzoni, Luca, Tosi, Benedetta, Pioner, Manuel J., Scellini, Beatrice, Piroddi, Nicoletta, Tardiff, Jil C., Tesi, Chiara, Cerbai, Elisabetta

Journal:

Biophysical Journal

Year:

2015

Language:

english

File:

PDF, 47 KB

english, 2015

48

Liver Kinase B1 complex acts as a novel modifier of myofilament function and localizes to the Z-disk in cardiac myocytes

Behunin, Samantha M., Lopez-Pier, Marissa A., Mayfield, Rachel M., Danilo, Christiane A., Lipovka, Yulia, Birch, Camille, Lehman, Sarah, Tardiff, Jil C., Gregorio, Carol C., Konhilas, John P.

Journal:

Archives of Biochemistry and Biophysics

Year:

2016

Language:

english

File:

PDF, 2.66 MB

english, 2016

49

The Role of Calcium/Calmodulin-Dependent Protein Kinase II Activation in Hypertrophic Cardiomyopathy

Tardiff, Jil C.

Journal:

Year:

2016

Language:

english

File:

PDF, 291 KB

english, 2016

50

11. Gene Therapy Mediated Increase in dATP Improves Cardiac Performance in Models of Systolic Heart Failure

Moussavi-Harami, Farid, Razumova, Maria V., Cheng, Yuanhua, Odom, Guy, Teichman, Sam, Tardiff, Jil, Hauschka, Stephen D., Chamberlain, Jeffrey S., Murry, Charles M., Regnier, Michael

Journal:

Molecular Therapy

Year:

2015

Language:

english

File:

PDF, 307 KB

english, 2015